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243 results
  • Raynaud's Phenomenon
  • Catharanthus roseus (L.)G.Don Apocynaceae. Madagascar Periwinkle Distribution: Madagascar. It is the source of vincristine and vinblastine, which impair cell multiplication by interfering with microtubule assembly, causing metaphase arrest and are effective medications for leukaemias, lymphomas and some solid tumours. The mortality from childhood leukaemia fell from 100% to 30% once it was introduced - not a drug that could ethically be tested by double-blind trials. These chemicals were initially discovered by investigators in 1958 who were looking for cures for diabetes so tested this plant which was being used in the West Indies to reduce blood sugar levels. There are 70 different alkaloids present in this plant, and some - catharanthine, leurosine sulphate, lochnerine, tetrahydroalstonine, vindoline and vindolinine - lower blood sugar levels. However, the toxicity of this plant is such that this is not a plant to try at home for diabetic management. The vincristine content of the plant is 0.0003%, so two kilograms of leaf are required to produce sufficient vincristine for a single course of treatment for a child (6gm). Fortunately it is a vigorous weed and easy to grow in the tropics. Artificial synthesis has now been achieved. Photographed in the Medicinal Garden of the Royal College of Physicians, London.
  • Neural stem cells in culture
  • HeLa cells, immortal human epithelial cancer cell line, SEM
  • Bioblasts
  • Graphite, SEM
  • Collagen fibres in human skin, LM
  • Origin of life
  • HeLa cell, immortal human epithelial cancer cell line, SEM
  • Thermogram of an infected middle finger, left hand.
  • HIV transcription, HIV viral life cycle, illustration
  • Rubus spectabilis 'Olympic Double'
  • Apoptosis
  • Imaginary Herbaria of Dr James Miranda Barry
  • Myxoid liposarcoma, microscopy
  • Human brain cancer stem cells treated with graphene, SEM
  • Raynaud's Phenomenon
  • Human tongue
  • Vanillin crystals, LM
  • Human saliva displaying ferning. During the fertile phase of a woman's menstrual cycle an oestrogen surge causes salt crystals to appear in the saliva. When viewed under the microscope the crystalline salt structure resembles fern leaves and can be used as an indication of a woman's increased chances of conceiving at this time.
  • Human dermis scar tissue
  • Bacterial microbiome mapping, bioartistic experiment
  • Bacterial microbiome mapping, bioartistic experiment
  • Human oral squamous cell carcinoma cell, SEM
  • Human femoral bone, AFM
  • Pulmonaria officinalis L. Boraginaceae Distribution: Officinalis indicates its medicinal use in early medicine. Europe. Pulmonaria or Lungwort are names for a lichen and a perennial plant in the Boraginaceae. This is the latter. Lyte (1578) has a woodcut of our plant and also calls it Sage of Jerusalem and says it is of ' no particular use in physicke, but is much used in meates and salads with eggs, as is also Cowslippes and Primroses, whereunto in temperature it is much alike.' He lists and describes the lichen separately. Culpeper (1650) said he found many sorts of lunguewort in perusing Authors ' Pulmonari, arborea and Symphytum maculosum [and the latter is our plant, the others the lichen] and that they 'helpe infirmities of the lungues, as hoarseness, coughs, wheezing, shortnesse of breath etc.' Coles (1657) who espouses the Doctrine of Signatures in a way unrivalled by any other English author, might have been expected to confirm the concept that the mottled leaves looked like the cut surface of a lung which indicates their purpose, but he only mentions the lungwort which is a lichen. However, Porta's beautiful book on the Doctrine, Phytognomica (1588), is clear that the plant called Pulmonaria with hairy leaves like a bugloss, spotted white with purple flowers, commonly called 'cynoglossa' [with a woodcut which could be Pulmonaria officinalis] indicate its use for ulcerated lungs, spitting blood, shortness of breath and asthma equally with the lichen with the same name. Lobel & Pena (1570) call it 'PULMONARIA, masculosa folia Borrago, floribus Primula veris, purpureis [PULMONARIA spotted, Borage-leaved, flowers like Primula veris - Cowslips - purple]' and say that women mix the leaves with a little broth and make it into an omelette for lung disorders and to strengthen the heart. Lobel (1576) calls it Maculosa Pulmonaria and describes a white flowered form with a good woodcut. Gerard (1633) uses the same woodcut as Lobel and calls it Pulmonatia foliis Echii, Buglosse Cowslips with red flowers, and a woodcut of a narrow leaved plant as Pulmonaria masculosa, Spotted Cowslips of Jerusalem with red, blue and purple flowers and says 'the leaves are used among pot-herbes. The roots are aso thought to be good against the infirmities of ulcers of the lungs...'. Quincy (1718) writes: '... it has a glutinous juice ... and heals ulcers and erosions. It is commended in coughs and spitting of blood but is little used either in the Shop or Prescriptions. Not used in modern medicine. It is in the family Boraginaceae whose species are often rich in pyrrolizidine alkaloids that cause liver toxicity and liver cancers, but levels in Pulmonaria officinalis may not be significant. Photographed in the Medicinal Garden of the Royal College of Physicians, London.
  • Origin of life
  • Camellia sasanqua Thunb. Theaceae. Christmas camellia. Camellia commemorates Georg Josef Kamel (1661-1706), Jesuit pharmacist from Moravia (Czech Republic) who worked in the Philippines and sent plants to John Ray in England (Oakeley, 2012) Evergreen shrub. Distribution: Japan and China. Leaves are used in Japan to make tea (normally made from C. sinensis) and the seeds to make the edible tea seed oil. Photographed in the Medicinal Garden of the Royal College of Physicians, London.
  • Thermogram of an infected middle finger, left hand.
  • HeLa cell, immortal human epithelial cancer cell line, SEM